Mitselou Antigony, Varouktsi Anna, Papadatos Stamatis S, Balasi Eugenia, Lampri Evangeli, Katsanos Konstantinos, Galani Vasiliki
University of Ioannina School of Health Sciences, Department of Forensic Medicine. Ioannina, Greece.
Ippokratio Hospital, Department of Internal Medicine. Thessaloníki, Greece.
Autops Case Rep. 2020 May 29;10(3):e2020145. doi: 10.4322/acr.2020.145.
Extragonadal non-gestational choriocarcinoma (ENC) is an uncommon malignant tumor occasionally found in the gastrointestinal tract. ENC is characterized by a biphasic tumor growth with distinct areas of adenocarcinoma and choriocarcinoma differentiation. Primary choriocarcinoma of the colon is extremely rare, with only 21 cases reported in the literature. Most of the perforation of colorectal cancers occurs in the abdominal cavity, while abdominal wall abscess is rare; the psoas abscess associated with colon carcinoma is even less observed. Herein, we report the case of a 61-year-old female with poorly differentiated adenocarcinoma of the ascending colon and sigmoid, with choriocarcinomatous differentiation, masquerading a psoas abscess formation. Unfortunately, despite the aggressive therapy, the patient's disease rapidly progressed, and she died within 2 months after the diagnosis. The typical morphological pattern, immunohistochemistry, and its correlation with serum β-human chorionic gonadotropin enabled a correct diagnosis.
性腺外非妊娠性绒毛膜癌（ENC）是一种罕见的恶性肿瘤，偶尔见于胃肠道。ENC的特征是肿瘤呈双相生长，有明显的腺癌和绒毛膜癌分化区域。原发性结肠绒毛膜癌极为罕见，文献中仅报道过21例。大多数结直肠癌穿孔发生在腹腔内，而腹壁脓肿罕见；与结肠癌相关的腰大肌脓肿更是少见。在此，我们报告一例61岁女性，升结肠和乙状结肠低分化腺癌伴绒毛膜癌分化，伪装成腰大肌脓肿形成。不幸的是，尽管进行了积极治疗，患者病情仍迅速进展，诊断后2个月内死亡。典型的形态学模式、免疫组化及其与血清β-人绒毛膜促性腺激素的相关性有助于做出正确诊断。
