螺内酯对去势前列腺癌男性患者血浆雄激素的抑制作用
Suppression of plasma androgens by spironolactone in castrated men with carcinoma of the prostate.
作者信息
Walsh P C, Siiteri P K
出版信息
J Urol. 1975 Aug;114(2):254-6. doi: 10.1016/s0022-5347(17)67001-0.
PMID:125803
Abstract
Spironolactone, an inhibitor of androgen synthesis, has been administered to castrated men with metastatic carcinoma of the prostate. Plasma levels of testosterone, androstenedione and dehydroepiandrosterone were significantly decreased. These data indicate that spironolactone suppresses adrenal androgen production and suggest that it may be of benefit in the treatment of orchiectomized patients with advanced carcinoma of the prostate.
摘要
螺内酯，一种雄激素合成抑制剂，已被用于治疗患有前列腺转移性癌的去势男性。睾酮、雄烯二酮和脱氢表雄酮的血浆水平显著降低。这些数据表明螺内酯可抑制肾上腺雄激素的产生，并提示其可能对治疗患有晚期前列腺癌的去势患者有益。
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