Wilson A J, Paris J, Luckins A G, Dar F K, Gray A R
Trop Anim Health Prod. 1976 Feb;8(1):1-12. doi: 10.1007/BF02383357.
Three groups of Boran cattle were maintained under different trypanocidal drug regimes for 29 months in an area of "medium" tsetse challenge. The development of immunity to trypanosmiasis in the cattle was assessed on the basis of changes in trypanocidal drug requirement, development of parasitaemia, ability to maintain normal blood values, growth and response to challenge after the withdrawal of the drugs. Observations were also made on serum antibody content by immunofluorescence and on serum immunoglobulin levels. Cattle treated with Berenil on the development of clinical disease developed a partial immunity to trypanosomiasis after two years. Cattle treated as a group with Berenil on the development of patent parasitaemia in any one animal of the group did not develop immunity. Cattle treated as a group with Samorin using the same criterion for treatment developed a degree of immunity to the disease. It was concluded that group treatment with Samorin was the most suitable of the three regimes examined for the maintenance of beef cattle is a tsetse infested area.
在一个采采蝇“中等”侵扰的地区，三组博拉牛在不同的杀锥虫药物方案下饲养了29个月。根据杀锥虫药物需求的变化、寄生虫血症的发展、维持正常血液值的能力、生长情况以及停药后对攻击的反应，评估了牛对锥虫病免疫力的发展。还通过免疫荧光观察了血清抗体含量，并检测了血清免疫球蛋白水平。在临床疾病出现时用贝尼尔治疗的牛，两年后对锥虫病产生了部分免疫力。在一组牛中，当任何一头牛出现显性寄生虫血症时用贝尼尔进行群体治疗，这些牛没有产生免疫力。按照相同的治疗标准用沙莫林对一组牛进行治疗，这些牛对该病产生了一定程度的免疫力。得出的结论是，在所研究的三种方案中，用沙莫林进行群体治疗是在采采蝇出没地区饲养肉牛最合适的方案。
