Fossati Philippe, Guillaume Le Bastard, Ergis Anne-Marie, Allilaire Jean-François
Department of Psychiatry, Salpêtrière Hospital, 47 Boulevard de l'Hôpital, 75651 Paris Cedex 13, France.
Psychiatry Res. 2003 Jan 25;117(1):17-24. doi: 10.1016/s0165-1781(02)00300-1.
The aim of this study was to analyze qualitative aspects of verbal fluency in depression. Phonemic and semantic output was scored for word clustering and switching between clusters in depressed patients and normal control subjects. Depressed patients (n=25) and normal control subjects (n=19) were administered both phonemic and semantic fluency tasks. All patients were also evaluated with executive card sorting tests. Patients with depression produced fewer words on the semantic fluency task than controls and showed normal performance on the phonemic fluency tasks. The deficit on semantic fluency of depressed patients was related to a reduced number of switches with normal cluster sizes. The number of switches in depression was associated with a reduced ability to shift mental set on card sorting tests, suggesting that verbal fluency impairment reflects general executive problems in depression.
本研究旨在分析抑郁症患者言语流畅性的质性方面。对抑郁症患者和正常对照者的音素和语义输出进行评分，以评估词语聚类及在聚类之间转换的情况。对25名抑郁症患者和19名正常对照者进行了音素和语义流畅性任务测试。所有患者还接受了执行功能卡片分类测试。抑郁症患者在语义流畅性任务中说出的词语比对照组少，而在音素流畅性任务中表现正常。抑郁症患者语义流畅性的缺陷与聚类大小正常但转换次数减少有关。抑郁症患者的转换次数与卡片分类测试中思维转换能力下降有关，这表明言语流畅性受损反映了抑郁症患者普遍存在的执行功能问题。
