Xiang Hui, Li Ruisheng, Liu Wenhui
Zhongshan University, Guangzhou 510275.
Zhong Yao Cai. 2002 Apr;25(4):275-7.
To study the lipid peroxidation products level in aged animals central nerve system and the antioxidation effect of the methol extract from Pegasus laternarius.
The lipid peroxidation product MDA was tested by spectrophotometer.
Compared with the 10 month-old guinea pig, the MDA in 32 month-old guinea pig central nerve system obviously elevated, there were some difference in different fields of tested guinea pig brain, the level of MDA in hypothalamus increased biggest (up to 161.7%), cerebral cortex 93.7%, cerebella 84.9%, brain stem 81.2%, spinal cord 90.7%, rest of the cerebrum 58.9%. The method extract from Pegasus laternarius 10, 20, 40 mg/kg and ginseng saponin 20 mg/kg could reduce the level of MDA in tested brain field of aged animals. The method extract from Pegasus laternarius had stronger activity in brain stem, spinal cord and hypothalamus.
The lipid peroxidation in aged animal may be increased, the method extract from Pegasus laternarius and ginseng saponin have a protective effect on neuron in central nerve system of aged animals from free radical hurt.
研究老年动物中枢神经系统脂质过氧化产物水平及海蛾甲醇提取物的抗氧化作用。
采用分光光度计检测脂质过氧化产物丙二醛（MDA）。
与10月龄豚鼠相比，32月龄豚鼠中枢神经系统MDA明显升高，在所测豚鼠脑不同区域存在差异，下丘脑MDA水平升高最大（达161.7%），大脑皮层为93.7%，小脑为84.9%，脑干为81.2%，脊髓为90.7%，大脑其余部分为58.9%。海蛾10、20、40mg/kg提取物及人参皂苷20mg/kg可降低老年动物所测脑区MDA水平。海蛾提取物在脑干、脊髓和下丘脑的活性较强。
老年动物脂质过氧化可能增强，海蛾提取物与人参皂苷对老年动物中枢神经系统神经元免受自由基损伤有保护作用。
