Perunicić G, Djukanović Lj, Pljesa S, Sević L
Nephrological Ward of Internal Service, University School of Medicine, Belgrade.
Srp Arh Celok Lek. 1996;124 Suppl 1:64-7.
The aim of the study was to determine the correlation between some clinical parameters and histopathologic findings in patients with lupus nephropathy. Eighteen patients (17 female and one male) with the diagnosis of lupus nephritis were examined at the Nephrological Clinical of the Faculty of Medicine. Three to eight months passed between diagnosing systemic lupus erithematosus and kidney biopsy. At the time of biopsy the average age of patients was 33.3 +/- 2.9 years (18-52 years). In more than half of the 18 cases the disease was evidenced as nephrotic syndrome, but most of them had renal failure and increased blood pressure. In patients with diffuse proliferative glomerulonephritis proteinuria was significantly higher than in other histopathologic groups. Serum nitrogen was considerably higher while creatinine clearance was much lower in patients with diffuse proliferative glomerulonephritis than in other histopathologic groups. Circulating immune complexes were increased, and the complement (C3 and C4) concentration was slower in patients with lupus nephropathy, but the significant difference was present only when diffuse glomerulonephritis was compared to other histopathologic groups.
本研究的目的是确定狼疮性肾病患者的一些临床参数与组织病理学结果之间的相关性。在医学院的肾脏病临床科室对18例诊断为狼疮性肾炎的患者（17例女性，1例男性）进行了检查。从诊断系统性红斑狼疮到进行肾活检间隔了3至8个月。活检时患者的平均年龄为33.3±2.9岁（18 - 52岁）。在这18例病例中，超过半数表现为肾病综合征，但大多数患者伴有肾衰竭和血压升高。弥漫性增殖性肾小球肾炎患者的蛋白尿明显高于其他组织病理学组。弥漫性增殖性肾小球肾炎患者的血清氮显著更高，而肌酐清除率则比其他组织病理学组低得多。狼疮性肾病患者循环免疫复合物增加，补体（C3和C4）浓度降低，但仅在将弥漫性肾小球肾炎与其他组织病理学组进行比较时存在显著差异。
