Krustev E, Konstantinov P, Vasilev V
Vet Med Nauki. 1976;13(1):48-52.
Chronic experiments were carried out with 62 guinea pigs (31 test and 31 control animals) which were given dipterex orally for 60 days at the rate of 100 mg/kg each. The effect was followed up of dipterex on the bactericidal properties of the blood, the phagocytic activity of some organs of the reticulo-endothelial system, the serum cholinesterase, the alkaline phosphatase, the hemoglobin and hematocrit values of the blood, and the proteinogram of the blood serum. A neglible drop of the gamma-globin fraction of the serum and the phagocytic activity of the immobile cells of the RES of the spleen and liver was found. The hemoglobin content decreased by 13.5 per cent, while the hematocrit value remained unchanged. At the amount given above dipterex suppressed by 50 per cent the activity of the serum cholinesterase, and increased by 36 per cent that of the alkaline phosphatase.
对62只豚鼠（31只试验动物和31只对照动物）进行了慢性实验，给它们每只按100毫克/千克的剂量口服敌百虫，持续60天。观察了敌百虫对血液杀菌性能、网状内皮系统某些器官的吞噬活性、血清胆碱酯酶、碱性磷酸酶、血液中的血红蛋白和血细胞比容值以及血清蛋白图谱的影响。发现血清γ-球蛋白部分和脾脏及肝脏网状内皮系统固定细胞的吞噬活性有轻微下降。血红蛋白含量下降了13.5%，而血细胞比容值保持不变。按上述剂量给予敌百虫时，血清胆碱酯酶活性被抑制了50%，碱性磷酸酶活性增加了36%。
