Facile construction and divergent transformation of polycyclic isoxazoles: direct access to polyketide architectures.

作者信息

Bode Jeffrey W, Hachisu Yoshifumi, Matsuura Tomoo, Suzuki Keisuke

机构信息

Department of Chemistry, Tokyo Institute of Technology, and CREST, Japan Science and Technology (JST) Corporation, O-okayama, Meguro-ku, Tokyo 152-8551, Japan.

出版信息

Org Lett. 2003 Feb 20;5(4):391-4. doi: 10.1021/ol027283f.

DOI:10.1021/ol027283f

PMID:12583726

Abstract

[reaction: see text] Base-promoted cyclocondensation of C-chloro oximes with cyclic 1,3-diketones affords functionalized isoxazoles in good yield and under convenient reaction conditions. This process enables the synthesis of highly substituted products with notable functional group tolerance. The products obtained are directly converted to a variety of polyketide-derived polycyclic structures including xanthenes, anthracenes, and benzophenones.

摘要