Goodman Allyson M, Pollack Murray M, Patel Kantilal M, Luban Naomi L C
Divisions of Critical Care Medicine, Children's Research Institute, George Washington University School of Medicine, Washington, DC 20010, USA.
J Pediatr. 2003 Feb;142(2):123-7. doi: 10.1067/mpd.2003.14.
To test the hypothesis that red blood cell transfusions are associated with increased resource utilization and mortality in critically ill children.
Five pediatric intensive care units (PICUs) participated in a retrospective, cohort analysis (1996-1999). Children with a hemoglobin value <or=9 g/dL during their PICU stay were enrolled. Data consisted of descriptive information, hemoglobin values, use of blood products, PICU resource use, and hospital mortality rate.
Among 240 children, 131 were transfused and 109 were not transfused. After controlling for the effects of other variables, transfusion was associated with an increase in days of oxygen use (4.48 +/- 1.37 days), days of mechanical ventilation (4.05 +/- 1.10 days), days of vasoactive agent infusions (1.27 +/- 0.44 days), and an increase of PICU and hospital lengths of stay (4.44 +/- 1.32, and 7.75 +/- 2.36 days, respectively).
Red blood cell transfusions are associated with an increase in resource utilization in critically ill children. The decision to transfuse patients should incorporate this potential morbidity.
检验红细胞输血与危重症儿童资源利用增加及死亡率升高相关的假说。
五个儿科重症监护病房（PICUs）参与了一项回顾性队列分析（1996 - 1999年）。纳入在PICU住院期间血红蛋白值≤9 g/dL的儿童。数据包括描述性信息、血红蛋白值、血液制品使用情况、PICU资源利用情况及医院死亡率。
在240名儿童中，131名接受了输血，109名未接受输血。在控制其他变量的影响后，输血与吸氧天数增加（4.48±1.37天）、机械通气天数增加（4.05±1.10天）、血管活性药物输注天数增加（1.27±0.44天）以及PICU和医院住院时间延长（分别为4.44±1.32天和7.75±2.36天）相关。
红细胞输血与危重症儿童资源利用增加相关。给患者输血的决策应考虑到这种潜在的发病率。
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