Hamoen Leendert W, Kausche Daisy, Marahiel Mohamed A, van Sinderen Douwe, Venema Gerard, Serror Pascale
Department of Genetics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, 9751 NN, Haren, The Netherlands.
FEMS Microbiol Lett. 2003 Jan 28;218(2):299-304. doi: 10.1111/j.1574-6968.2003.tb11532.x.
Genetic competence is a differentiation process initiated by Bacillus subtilis as a result of nutritional deprivation, and is controlled by a complex signal transduction cascade. The promoter of comK, encoding the competence transcription factor, is regulated by at least four different transcription factors: Rok, CodY, DegU and ComK itself. Genetic data have shown that comK expression is influenced by the transition state regulator AbrB as well. In this paper we show that AbrB binds specifically to the comK promoter and covers the RNA polymerase binding site, making it the fifth transcription factor regulating the activity of the comK promoter.
遗传感受态是枯草芽孢杆菌由于营养匮乏而启动的一个分化过程，由一个复杂的信号转导级联反应控制。编码感受态转录因子的comK的启动子至少受四种不同转录因子调控：Rok、CodY、DegU和ComK自身。遗传学数据表明，comK的表达也受过渡态调节因子AbrB的影响。在本文中，我们表明AbrB特异性结合comK启动子并覆盖RNA聚合酶结合位点，使其成为调控comK启动子活性的第五种转录因子。
