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Physiological and genetic factors affecting transformation of Bacillus subtilis.影响枯草芽孢杆菌转化的生理和遗传因素。
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Genetic networks controlling the initiation of sporulation and the development of genetic competence in Bacillus subtilis.控制枯草芽孢杆菌孢子形成起始和遗传感受态发育的遗传网络。
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Interaction of CodY, a novel Bacillus subtilis DNA-binding protein, with the dpp promoter region.新型枯草芽孢杆菌DNA结合蛋白CodY与dpp启动子区域的相互作用。
Mol Microbiol. 1996 May;20(4):843-52. doi: 10.1111/j.1365-2958.1996.tb02522.x.
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Role of CodY in regulation of the Bacillus subtilis hut operon.CodY在枯草芽孢杆菌hut操纵子调控中的作用。
J Bacteriol. 1996 Jul;178(13):3779-84. doi: 10.1128/jb.178.13.3779-3784.1996.
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Amino-acylation site mutations in amino acid-activating domains of surfactin synthetase: effects on surfactin production and competence development in Bacillus subtilis.表面活性素合成酶氨基酸激活结构域中的氨酰化位点突变：对枯草芽孢杆菌表面活性素产生及感受态发育的影响
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Sequence and properties of mecA, a negative regulator of genetic competence in Bacillus subtilis.枯草芽孢杆菌遗传感受态负调控因子mecA的序列与特性
Mol Microbiol. 1993 Jul;9(2):365-73. doi: 10.1111/j.1365-2958.1993.tb01697.x.
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ComA, a phosphorylated response regulator protein of Bacillus subtilis, binds to the promoter region of srfA.ComA是枯草芽孢杆菌的一种磷酸化应答调节蛋白，它与srfA的启动子区域结合。
J Bacteriol. 1993 May;175(10):3182-7. doi: 10.1128/jb.175.10.3182-3187.1993.
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Mutations that relieve nutritional repression of the Bacillus subtilis dipeptide permease operon.解除枯草芽孢杆菌二肽通透酶操纵子营养阻遏的突变
J Bacteriol. 1993 Aug;175(15):4605-14. doi: 10.1128/jb.175.15.4605-4614.1993.
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Molecular cloning and sequence of comK, a gene required for genetic competence in Bacillus subtilis.枯草芽孢杆菌遗传感受态所需基因comK的分子克隆与序列分析
Mol Microbiol. 1994 Feb;11(4):695-703. doi: 10.1111/j.1365-2958.1994.tb00347.x.
10
Plasmids designed to alter the antibiotic resistance expressed by insertion mutations in Bacillus subtilis, through in vivo recombination.通过体内重组设计的质粒，用于改变枯草芽孢杆菌插入突变所表达的抗生素抗性。
Gene. 1994 May 3;142(1):79-83. doi: 10.1016/0378-1119(94)90358-1.

枯草芽孢杆菌遗传感受态的营养抑制需要CodY。

CodY is required for nutritional repression of Bacillus subtilis genetic competence.

作者信息

Serror P, Sonenshein A L

机构信息

Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.

出版信息

J Bacteriol. 1996 Oct;178(20):5910-5. doi: 10.1128/jb.178.20.5910-5915.1996.

DOI:10.1128/jb.178.20.5910-5915.1996
PMID:8830686
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC178446/
Abstract

The acquisition of genetic competence by Bacillus subtilis is repressed when the growth medium contains Casamino Acids. This repression was shown to be exerted at the level of expression from the promoters of the competence-regulatory genes srfA and comK and was relieved in strains carrying a null mutation in the codY gene. DNase I footprinting experiments showed that purified CodY binds directly to the srfA and comK promoter regions.

摘要

当生长培养基中含有酪蛋白氨基酸时，枯草芽孢杆菌的遗传感受态的获得受到抑制。这种抑制作用在感受态调节基因srfA和comK启动子的表达水平上发挥作用，并且在携带codY基因无效突变的菌株中得到缓解。DNA酶I足迹实验表明，纯化的CodY直接与srfA和comK启动子区域结合。