Sharma Mukesh Kumar, Kumar Madhu, Kumar Ashok
Department of Zoology, University of Rajasthan, Jaipur, 302 004, India.
Indian J Exp Biol. 2002 Sep;40(9):1079-82.
HgCl2 (5.0 mg/kg body weight) induced toxicity led to significant elevation of lipid peroxidation (LPO) level but decline in the glutathione content in liver of Swiss albino mice. In serum of HgCl2 treated mice there was significant elevation in serum glutamate oxaloacetate transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT) activities but significant decline in the alkaline phosphatase activity. Animals treated with O. sanctum extract (10 mg/kg body weight, po) before and after mercury intoxication showed a significant decrease in LPO level, SGOT and SGPT activities and increase in serum alkaline phosphatase activity and glutathione (GSH) content. Ocimum treatment alone did not alter SGOT, SGPT and alkaline phosphatase activities but significantly enhanced reduced glutathione. The results suggest that oral administration of Ocimum extract provides protection against HgCl2 induced toxicity in Swiss albino mice.
氯化汞（5.0毫克/千克体重）诱导的毒性导致瑞士白化小鼠肝脏中脂质过氧化（LPO）水平显著升高，但谷胱甘肽含量下降。在经氯化汞处理的小鼠血清中，血清谷氨酸草酰乙酸转氨酶（SGOT）和血清谷氨酸丙酮酸转氨酶（SGPT）活性显著升高，但碱性磷酸酶活性显著下降。在汞中毒前后用圣洁罗勒提取物（10毫克/千克体重，口服）处理的动物，其LPO水平、SGOT和SGPT活性显著降低，血清碱性磷酸酶活性和谷胱甘肽（GSH）含量增加。单独使用罗勒处理未改变SGOT、SGPT和碱性磷酸酶活性，但显著增强了还原型谷胱甘肽。结果表明，口服罗勒提取物可对瑞士白化小鼠的氯化汞诱导毒性起到保护作用。
