Gatenby P, Tucko R, Andrews C, O'Neil R
Department of Immunopathology, The Canberra Hospital and the Canberra Clinical School, University of Sydney, Garran, ACT, Australia.
Lupus. 2003;12(1):58-62. doi: 10.1191/0961203303lu240cr.
Two patients with Down syndrome and the primary antiphospholipid antibody are described. One patient had a vasculopathy similar to that previously described as Moyamoya. Down syndrome is characterized by immune defects including a tendency to autoimmune phenomena. This report extends the scope of these observations and particularly draws out the potential role of antiphospholipid antibodies. Indeed antiphospholipid antibodies may well explain the well-known association of Down syndrome and stroke.
本文描述了两名患有唐氏综合征和原发性抗磷脂抗体的患者。其中一名患者患有与先前描述的烟雾病相似的血管病变。唐氏综合征的特征是存在免疫缺陷，包括有自身免疫现象的倾向。本报告扩展了这些观察结果的范围，尤其突出了抗磷脂抗体的潜在作用。事实上，抗磷脂抗体很可能解释了唐氏综合征与中风之间众所周知的关联。
