Tzouvelekis L S, Lukova V, Tassios P T, Fluit A C, Jones R N, Legakis N J
Department of Microbiology, Medical School, University of Athens, Athens, Greece.
Clin Microbiol Infect. 2003 Feb;9(2):149-52. doi: 10.1046/j.1469-0691.2003.00507.x.
The susceptibility to beta-lactams and the beta-lactamase content of 110 Salmonella spp. blood isolates collected during 1997-98 in 19 European centers participating in the SENTRY Surveillance Program were studied. Thirty-one isolates (28%) were resistant to penicillins, due to production of TEM-1 (27 isolates), OXA-1 (three isolates) or TEM-1 + OXA-1 (one isolate). All OXA-1 producers and 10 TEM-1-producing isolates were also resistant to penicillin-clavulanic acid combinations. In the latter isolates, this phenotype was associated with increased production of TEM-1. Sixteen TEM-1-producing Salmonella Enteritidis isolates and one OXA-1-producing S. Typhimurium isolate were able to transfer beta-lactam resistance by conjugation.
对参与哨兵监测计划的19个欧洲中心在1997 - 1998年期间收集的110株沙门氏菌属血液分离株对β-内酰胺类药物的敏感性和β-内酰胺酶含量进行了研究。31株分离株（28%）对青霉素耐药，原因是产生了TEM-1（27株）、OXA-1（3株）或TEM-1 + OXA-1（1株）。所有产生OXA-1的菌株和10株产生TEM-1的菌株也对青霉素 - 克拉维酸组合耐药。在后者的分离株中，这种表型与TEM-1产量增加有关。16株产生TEM-1的肠炎沙门氏菌分离株和1株产生OXA-1的鼠伤寒沙门氏菌分离株能够通过接合转移β-内酰胺耐药性。
