听觉放大：外毛细胞是关键所在。 （你提供的原文“pres”可能有误，推测应该是“are”，正确句子可能是“Auditory amplification: outer hair cells are the issue.” ）
Auditory amplification: outer hair cells pres the issue.
作者信息
Géléoc Gwénaëlle S G, Holt Jeffrey R
机构信息
Department of Neuroscience, University of Virginia, PO Box 801392, Charlottesville, VA 22908, USA.
出版信息
Trends Neurosci. 2003 Mar;26(3):115-7. doi: 10.1016/S0166-2236(03)00030-4.
Active feedback mechanisms in the ears of mammals amplify and tune the auditory response to sound stimuli, allowing these organisms to enjoy both exquisite sensitivity and sharp frequency selectivity. A requisite component of this feedback pathway has recently been identified. Targeted deletion of pres, the gene that encodes the novel membrane-bound motor protein prestin, has revealed a hundred-fold loss in hearing sensitivity suggesting that it might be part of the elusive cochlear amplifier.
哺乳动物耳朵中的主动反馈机制会放大并调节对声音刺激的听觉反应，使这些生物既能拥有极高的灵敏度，又具备敏锐的频率选择性。最近已确定了这一反馈通路的一个必要组成部分。对编码新型膜结合运动蛋白prestin的基因pres进行靶向缺失，结果显示听力灵敏度下降了一百倍，这表明它可能是难以捉摸的耳蜗放大器的一部分。
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