Qi Jieyu, Zhang Liyan, Wang Xiaohan, Chen Xin, Li Yiyuan, Wang Tian, Wu Peina, Chai Renjie
State Key Laboratory of Digital Medical Engineering Department of Otolaryngology Head and Neck Surgery Zhongda Hospital School of Life Sciences and Technology Advanced Institute for Life and Health Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research Southeast University Nanjing China.
Co-Innovation Center of Neuroregeneration Nantong University Nantong China.
Smart Med. 2024 Jan 16;3(1):e20230028. doi: 10.1002/SMMD.20230028. eCollection 2024 Feb.
More than 6% of the world's population is suffering from hearing loss and balance disorders. The inner ear is the organ that senses sound and balance. Although inner ear disorders are common, there are limited ways to intervene and restore its sensory and balance functions. The development and establishment of biologically therapeutic interventions for auditory disorders require clarification of the basics of signaling pathways that control inner ear development and the establishment of endogenous or exogenous cell-based therapeutic methods. In vitro models of the inner ear, such as organoid systems, can help identify new protective or regenerative drugs, develop new gene therapies, and be considered as potential tools for future clinical applications. Advances in stem cell technology and organoid culture offer unique opportunities for modeling inner ear diseases and developing personalized therapies for hearing loss. Here, we review and discuss the mechanisms for the establishment and the potential applications of inner ear organoids.
全球超过6%的人口患有听力损失和平衡障碍。内耳是感知声音和平衡的器官。尽管内耳疾病很常见，但干预并恢复其感觉和平衡功能的方法有限。开发针对听觉障碍的生物治疗干预措施需要阐明控制内耳发育的信号通路基础，并建立基于内源性或外源性细胞的治疗方法。内耳的体外模型，如类器官系统，有助于识别新的保护性或再生性药物、开发新的基因疗法，并被视为未来临床应用的潜在工具。干细胞技术和类器官培养的进展为模拟内耳疾病和开发针对听力损失的个性化疗法提供了独特的机会。在此，我们对内耳类器官的建立机制及其潜在应用进行综述和讨论。
