Posner M A, Rodkey F L, Tobey R E
Anesthesiology. 1976 Apr;44(4):330-5. doi: 10.1097/00000542-197604000-00011.
Sodium nitroprusside was investigated as a potential source of cyanide poisoning, Whole-blood cyanide determinations were performed on arterial samples from baboons receiving nitroprusside while anesthetized. There was a statistically significant increase in cyanide levels, as well as development of tachyphylaxis and severe metabolic acidosis. Hydroxocobalamin (vitamin B12a) infused simultaneously with nitroprusside significantly lessened the increase in cyanide levels and eliminated the development of metabolic acidosis. Nitroprusside can cause cyanide intoxication in the baboon, and hydroxocobalamin appears to be an effective antidote.
研究了硝普钠作为氰化物中毒潜在来源的情况。对麻醉状态下接受硝普钠的狒狒的动脉样本进行了全血氰化物测定。氰化物水平有统计学意义的升高，同时出现快速耐受性和严重代谢性酸中毒。与硝普钠同时输注的羟钴胺素（维生素B12a）显著减轻了氰化物水平的升高，并消除了代谢性酸中毒的发生。硝普钠可导致狒狒氰化物中毒，而羟钴胺素似乎是一种有效的解毒剂。
