Plecko Vanda, Kalenić Smilja, Presecki Vladimir, Dominis Mara, Katicić Miroslava
Klinicki bolnicki centar Zagreb, Zavod za klinicku i molekularnu mikrobiologiju, Kispatićeva 12, 10000 Zagreb.
Lijec Vjesn. 2002 Sep;124 Suppl 1:20-3.
Bacteriological diagnosis of Helicobacter pylori consists of culture from gastric biopsies, gastric juice, faeces and from specimens obtained from oral cavity, antigen stool assay and molecular diagnostic methods. In routine work culture is done from gastric biopsies. Other specimens are usually cultivated for research purposes. Culture constitutes the most specific way to establish the diagnosis of H. pylori infection. One of the major advantages of culture is that it allows sensitivity testing to drugs used in therapy. Culture also allows characterisation of H. pylori. Antigen stoll assay is a non-invasive diagnostic procedure, which should be evaluated. Molecular methods have confirmed their potential for epidemiological research and for the detection of resistant H. pylori, especially for macrolides. The clinical settings, local availability and economic considerations should guide use of bacteriological diagnostic methods.
幽门螺杆菌的细菌学诊断包括对胃活检组织、胃液、粪便以及从口腔获取的标本进行培养、粪便抗原检测和分子诊断方法。在日常工作中，通过胃活检组织进行培养。其他标本通常用于研究目的。培养是确立幽门螺杆菌感染诊断的最特异方法。培养的主要优点之一是它能对治疗中使用的药物进行敏感性测试。培养还能对幽门螺杆菌进行特性鉴定。粪便抗原检测是一种非侵入性诊断程序，应予以评估。分子方法已证实其在流行病学研究和检测耐药幽门螺杆菌（尤其是对大环内酯类耐药的幽门螺杆菌）方面的潜力。临床情况、当地可获得性和经济因素应指导细菌学诊断方法的使用。
