[原发性心脏淋巴瘤：2例免疫功能正常患者的病例报告]
[Primary cardiac lymphoma: presentation of two cases in immunocompetent patients].
作者信息
Mayayo Artal E, Balanzá Roure R, Font Ferré L, Alvaro Naranjo T
机构信息
Servicio de Patología, Hospital Universitario de Tarragona Joan XXIII, Tarragona.
出版信息
An Med Interna. 2002 Dec;19(12):629-31.
BACKGROUND
Primary cardiac lymphomas (PCL) are extremely rare in immunocompetent patients. Their pathogenesis seems obscure and a few studies which have sought Epstein Barr virus (EBV) agree that this is generally not demonstrable.
CASES
Two cases of cardiac lymphoma have been described. In both cases, as usually occurs, the histological diagnosis was performed after post-mortem examination. Histological examinations revealed a B large cell lymphoma in both patients. Autopsy material from both cases showed an inflammatory focus distant from the tumoral mass. EBERs and LMP for EBV were negative.
CONCLUSIONS
PCLs are often fast-growing tumours with a highly unfavorable prognosis. Epstein-Barr virus appears to play no role in the development of this malignant condition.
背景
原发性心脏淋巴瘤（PCL）在免疫功能正常的患者中极为罕见。其发病机制似乎尚不明确，一些对爱泼斯坦-巴尔病毒（EBV）进行研究的结果表明，通常无法证实该病毒与发病有关。
病例
本文描述了两例心脏淋巴瘤病例。与通常情况一样，两例均在尸检后进行了组织学诊断。组织学检查显示两名患者均为B大细胞淋巴瘤。两例的尸检材料均显示在远离肿瘤块处有一个炎症灶。EBV的EBERs和LMP检测均为阴性。
结论
PCL通常是生长迅速的肿瘤，预后极差。爱泼斯坦-巴尔病毒似乎在这种恶性疾病的发生发展中不起作用。
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