爱泼斯坦-巴尔病毒和人类免疫缺陷病毒阴性的口腔浆母细胞淋巴瘤
Epstein-Barr virus and human immunodeficiency virus-negative oral plasmablastic lymphoma.
作者信息
Lee Ok-Jun, Kim Kyoung-Won, Lee Geon Kook
机构信息
Department of Pathology, Chungbuk National University College of Medicine, Cheongju-si, Korea.
出版信息
J Oral Pathol Med. 2006 Jul;35(6):382-4. doi: 10.1111/j.1600-0714.2006.00422.x.
Plasmablastic lymphoma (PBL) is an unusual subtype of human immunodeficiency virus (HIV)-related diffuse large B-cell lymphoma that was first described in the oral cavity. HIV-related lymphomas are frequently associated with Epstein-Barr virus (EBV). Recently, dual infection with EBV and human herpesvirus 8 (HHV8) has been demonstrated in PBL. So far, a few cases of PBL occurring in an HIV-negative patient have been documented and all of them were associated with immunosuppression status and/or EBV infection. Here we report a EBV and HHV8-negative oral PBL occurring in an immunocompetent HIV-negative male, which would be the first case.
浆母细胞淋巴瘤（PBL）是人类免疫缺陷病毒（HIV）相关弥漫性大B细胞淋巴瘤的一种罕见亚型，最初在口腔中被描述。HIV相关淋巴瘤常与EB病毒（EBV）有关。最近，在PBL中已证实存在EBV和人类疱疹病毒8型（HHV8）的双重感染。到目前为止，已记录了几例发生在HIV阴性患者中的PBL病例，所有这些病例都与免疫抑制状态和/或EBV感染有关。在此，我们报告一例发生在免疫功能正常的HIV阴性男性中的EBV和HHV8阴性口腔PBL，这将是首例此类病例。
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