念珠菌属产生的β-吲哚乙醇和β-吲哚乳酸：它们的抗菌和自身抗生素作用。
Beta-indoleethanol and beta-indolelactic acid production by Candida species: their antibacterial and autoantibiotic action.
作者信息
Narayanan T K, Rao G R
出版信息
Antimicrob Agents Chemother. 1976 Mar;9(3):375-80. doi: 10.1128/AAC.9.3.375.
Abstract
Candida spp. grown in synthetic medium supplemented with l-tryptophan as sole nitrogen source produced beta-indoleethanol (beta-IEA) and beta-indolelactic acid (beta-ILA). These compounds isolated from the culture filtrates were characterized by ultraviolet, infrared, and nuclear magnetic resonance spectral studies. Using dl-[(3)H]trypotophan in the medium, labeled beta-IEA and beta-ILA were isolated. Further, beta-IEA was produced as a result incubating log-phase cells of C. albicans with beta-ILA. Both beta-IEA and beta-ILA inhibited the growth of gram-positive and -negative bacteria. Autoantibiotic action of these compounds on Candida spp. and the reversal of this inhibition were studied.
摘要
在以L-色氨酸作为唯一氮源的合成培养基中培养的念珠菌属产生了β-吲哚乙醇（β-IEA）和β-吲哚乳酸（β-ILA）。从培养滤液中分离出的这些化合物通过紫外、红外和核磁共振光谱研究进行了表征。在培养基中使用dl-[(3)H]色氨酸，分离出了标记的β-IEA和β-ILA。此外，白色念珠菌的对数期细胞与β-ILA孵育会产生β-IEA。β-IEA和β-ILA均抑制革兰氏阳性和阴性细菌的生长。研究了这些化合物对念珠菌属的自抗生素作用以及这种抑制作用的逆转。
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本文引用的文献
1
Indole Compounds Synthesized by Diplodia natalensis.由纳塔尔葡萄座腔菌合成的吲哚化合物。
Plant Physiol. 1962 May;37(3):439-45. doi: 10.1104/pp.37.3.439.
2
On the metabolism of tryptophan by Agrobacterium tumefaciens.关于根癌土壤杆菌对色氨酸的代谢
Biochim Biophys Acta. 1958 Nov;30(2):401-20. doi: 10.1016/0006-3002(58)90065-9.
3
Phenethyl alcohol and tryptophol: autoantibiotics produced by the fungus Candida albicans.苯乙醇和色醇：白色念珠菌产生的自身抗生素。
Science. 1969 Jan 10;163(3863):192-4. doi: 10.1126/science.163.3863.192.
4
[Indole-3-lactic acid and its metabolism by Rhizobium].[吲哚-3-乳酸及其在根瘤菌中的代谢]
Arch Mikrobiol. 1970;72(4):297-307.
5
[Synthesis of indolyl-3-lactic acid and tryptophol by Rhizobium cultivated in the presence of tryptophan].[在色氨酸存在下培养的根瘤菌合成吲哚-3-乳酸和色醇]
C R Acad Hebd Seances Acad Sci D. 1966 Jan 3;262(1):100-2.
6
Production of 2-phenethyl alcohol and 2-phenyllactic acid in Candida species.念珠菌属中2-苯乙醇和2-苯乳酸的产生。
Biochem Biophys Res Commun. 1974 Jun 4;58(3):728-35. doi: 10.1016/s0006-291x(74)80478-x.
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