阴道HIV传播中的靶细胞。
Target cells in vaginal HIV transmission.
作者信息
Miller Christopher J, Shattock Robin J
机构信息
Department of Veterinary Pathology, Microbiology and Immunology, Center for Comparative Medicine, School of Veterinary Medicine, California National Primate Research Center, University of California-Davis, Davis, CA 95616, USA.
出版信息
Microbes Infect. 2003 Jan;5(1):59-67. doi: 10.1016/s1286-4579(02)00056-4.
Understanding the mechanisms of HIV transmission to women will be crucial to the development of effective strategies to curb this epidemic. Current data suggest that HIV has at least two routes to penetrate the vaginal epithelium and reach lymphoid tissues, trans-epithelial migration of infected Langerhans cells or virus penetration into the lamina propria through loss of epithelial integrity resulting in direct infection of lymphocytes, dendritic cells and macrophages.
了解艾滋病毒传播给女性的机制对于制定有效的遏制这一流行病的策略至关重要。目前的数据表明，艾滋病毒至少有两条途径穿透阴道上皮并到达淋巴组织，即受感染的朗格汉斯细胞的跨上皮迁移，或病毒通过上皮完整性丧失进入固有层，从而直接感染淋巴细胞、树突状细胞和巨噬细胞。
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