神经发育中的细胞周期与细胞命运相互作用

Cell cycle and cell fate interactions in neural development.

作者信息

Cremisi Federico, Philpott Anna, Ohnuma Shin-ichi

机构信息

Scuola Normale Superiore/Dipartimento di Fisiologia e Biochimica, Sezione di Biologia Cellulare e dello Sviluppo, Università di Pisa, Via Carducci 13, Ghezzano, 56010, Pisa, Italy.

出版信息

Curr Opin Neurobiol. 2003 Feb;13(1):26-33. doi: 10.1016/s0959-4388(03)00005-9.

DOI:10.1016/s0959-4388(03)00005-9

PMID:12593979

Abstract

Mechanisms coupling cell cycle and cell fate operate at different steps during neural development. Intrinsic factors control the cell proliferation of distinct brain regions and changes of cell fate competence, whereas components of the cell cycle machinery could play a major role in setting the appropriate timing of the generation of different cell types.

摘要

在神经发育过程中，耦合细胞周期与细胞命运的机制在不同步骤发挥作用。内在因素控制着不同脑区的细胞增殖以及细胞命运潜能的变化，而细胞周期机制的组成部分可能在设定不同细胞类型产生的合适时间方面发挥主要作用。