消防员与睾丸癌风险：一项基于德国人群的病例对照研究结果
Firefighting and risk of testicular cancer: results from a German population-based case-control study.
作者信息
Stang Andreas, Jöckel Karl-Heinz, Baumgardt-Elms Cornelia, Ahrens Wolfgang
机构信息
Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Hufelandstr. Essen, Germany.
出版信息
Am J Ind Med. 2003 Mar;43(3):291-4. doi: 10.1002/ajim.10178.
BACKGROUND
There is some evidence of an elevated risk for testicular cancer among firefighters.
METHODS
We performed a population-based case-control study including 269 testicular cancer cases and 797 controls matching on age and region with a special focus on occupational exposures. Job tasks were coded according to the International Standard Classification of Occupations (ISCO 68). We used conditional logistic regression to calculate odds ratios (OR).
RESULTS
Three controls (0.4%) and four cases (1.5%) ever worked as firefighters. Firefighters showed an increased odds of testicular cancer in the matched evaluation (OR = 4.3, 95% confidence interval (95% CI) 0.7-30.5). The adjustment for a history of cryptorchidism or family history of testicular cancer did not alter our results.
CONCLUSION
Although the association between firefighting and testicular cancer risk is based on only small numbers of exposed subjects in our study, the finding is consistent with a recent cohort study from New Zealand. Occupational hazards experienced by firefighters may increase the risk of testicular cancer.
背景
有证据表明消防员患睾丸癌的风险有所升高。
方法
我们开展了一项基于人群的病例对照研究，纳入269例睾丸癌病例和797例年龄及地区匹配的对照，特别关注职业暴露情况。工作任务根据《国际职业分类标准》（ISCO 68）进行编码。我们使用条件逻辑回归来计算比值比（OR）。
结果
3名对照（0.4%）和4例病例（1.5%）曾担任消防员。在匹配评估中，消防员患睾丸癌的几率增加（OR = 4.3，95%置信区间（95%CI）0.7 - 30.5）。对隐睾病史或睾丸癌家族史进行调整并未改变我们的结果。
结论
尽管在我们的研究中，消防员与睾丸癌风险之间的关联仅基于少量暴露个体，但这一发现与新西兰最近的一项队列研究一致。消防员所经历的职业危害可能会增加患睾丸癌的风险。
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