Bates Michael N
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California 94720-7360, USA.
Am J Ind Med. 2007 May;50(5):339-44. doi: 10.1002/ajim.20446.
There is no consensus whether firefighters are at increased cancer risk for particular cancers. Previous studies have been small, mostly investigated cancer mortality, and suggested increased risks for brain, bladder, testicular, prostate, thyroid and colo-rectal cancers, leukemia, and melanoma.
Records of all male cancers registered in California during 1988-2003 were obtained. Firefighters were identified from occupation and industry text fields. Logistic regression analysis used other cancers as controls.
Of the 804,000 eligible records, 3,659 had firefighting as their occupation. Firefighting was associated with testicular cancer (odds ratio = 1.54, 95% confidence interval: 1.18-2.02), melanoma (1.50, 1.33-1.70), brain cancer (1.35, 1.06-1.72), esophageal cancer (1.48, 1.14-1.91), and prostate cancer (1.22, 1.12-1.33).
Use of other-cancer controls and lack of an occupational history may have biased relative risks towards the null. However, this study, which contained more firefighter cancers than any previous epidemiologic study, produced evidence supporting some prior hypotheses.
消防员患特定癌症的风险是否增加尚无定论。以往的研究规模较小，大多调查癌症死亡率，并提示患脑癌、膀胱癌、睾丸癌、前列腺癌、甲状腺癌和结直肠癌、白血病以及黑色素瘤的风险增加。
获取了1988年至2003年加利福尼亚州登记的所有男性癌症记录。通过职业和行业文本字段识别消防员。逻辑回归分析以其他癌症作为对照。
在804,000条合格记录中，有3,659条记录显示职业为消防员。消防员患睾丸癌（优势比=1.54，95%置信区间：1.18 - 2.02）、黑色素瘤（1.50，1.33 - 1.70）、脑癌（1.35，1.06 - 1.72）、食管癌（1.48，1.14 - 1.91）和前列腺癌（1.22，1.12 - 1.33）的风险增加。
使用其他癌症作为对照以及缺乏职业史可能使相对风险偏向于零。然而，这项研究纳入的消防员患癌病例比以往任何流行病学研究都多，为一些先前的假设提供了支持证据。
