Litwak R S, Koffsky R M, Jurado R A, Lukban S B, Ortiz A F, Fischer A P, Sherman J J, Silvay G, Lajam F A
Ann Thorac Surg. 1976 Mar;21(3):191-202. doi: 10.1016/s0003-4975(10)64291-9.
A left heart assist device (LHAD) has been employed in 14 patients. All had advanced heart disease and were in low cardiac output after repair, such that they could not be separated from cardiopulmonary bypass despite prolonged support and adjuvant therapy, including drugs, pacing, and use of intraaortic balloon counterpulsation whenever possible. Apart from special cannulas, the equipment necessary for the LHAD is widely available. An asset of the system (left atrial-ascending aorta bypass of the left ventricle) is that it may be terminated without reentering the thorax to remove the cannulas. This is accomplished with precisely fitting obturators that obliterate the cannula lumens and allow the tubes to be permanently implanted. This concept is believed important since critically ill patients requiring support are precisely those in whom added risk would be imposed by a second operation. Of the 14 patients who have had intraoperative and postoperative support (up to 6.8 days), 9 were weaned from the device and 6 were dismissed from the hospital. Four patients remain alive and are improved, the longest at 22 months since operation. The favorable performance of the LHAD suggests that it may prove useful either when intraaortic balloon counterpulsation cannot be successfully deployed or when it has failed to achieve hemodynamic stability.
14例患者使用了左心辅助装置(LHAD)。所有患者均患有晚期心脏病,术后心输出量低,尽管进行了长时间的支持治疗和辅助治疗,包括药物、起搏以及尽可能使用主动脉内球囊反搏,仍无法脱离体外循环。除了特殊的插管外,LHAD所需的设备广泛可得。该系统(左心室左心房 - 升主动脉旁路)的一个优点是,无需再次开胸取出插管即可终止使用。这通过精确适配的闭孔器来实现,闭孔器可封闭插管腔,使管道能够永久植入。这一概念被认为很重要,因为需要支持的重症患者恰恰是那些进行二次手术会增加风险的患者。在14例接受术中及术后支持(长达6.8天)的患者中,9例成功撤掉该装置,6例出院。4例患者存活且病情好转,术后最长存活时间为22个月。LHAD的良好性能表明,当主动脉内球囊反搏无法成功应用或未能实现血流动力学稳定时,它可能会被证明是有用的。