Department of Pharmacy, Federal University of Pernambuco, Avenida Professor Moraes Rego 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
Department of Antibiotics, Federal University of Pernambuco, Avenida Professor Moraes Rego 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
Biomed Res Int. 2014;2014:316082. doi: 10.1155/2014/316082. Epub 2014 May 7.
Antibiotic resistance is considered one of the world's major public health concerns. The main cause of bacterial resistance is the improper and repeated use of antibiotics. To alleviate this problem, new chemical substances against microorganisms are being synthesized and tested. Thiazolidines are compounds having many pharmacological activities including antimicrobial activities. For this purpose some thiazolidine derivatives substituted at position 5 in the thiazolidine nucleus were synthesized and tested against several microorganisms. Using a disc diffusion method, antimicrobial activity was verified against Gram-positive, Gram-negative, and alcohol acid resistant bacteria and yeast. The minimum inhibition concentrations (MIC) and minimum bactericidal concentrations (MBC) were determined. All derivatives showed antimicrobial activity mainly against Gram-positive bacteria, with MIC values ranging from 2 to 16 µg/mL.
抗生素耐药性被认为是世界主要公共卫生关注点之一。细菌耐药性的主要原因是抗生素的不当和重复使用。为了缓解这个问题，正在合成和测试新的针对微生物的化学物质。噻唑烷类化合物具有许多药理活性，包括抗菌活性。为此，合成了一些噻唑烷核 5 位取代的噻唑烷衍生物，并对几种微生物进行了测试。采用圆盘扩散法，对抗革兰氏阳性菌、革兰氏阴性菌、耐酸酒精菌和酵母进行了抗菌活性验证。测定了最小抑菌浓度（MIC）和最小杀菌浓度（MBC）。所有衍生物均表现出抗菌活性，主要针对革兰氏阳性菌，MIC 值范围为 2 至 16 μg/mL。
