Greenberg A S, Coleman M
Arch Gen Psychiatry. 1976 Mar;33(3):331-6. doi: 10.1001/archpsyc.1976.01770030045006.
Monitoring of 5-hydroxyindole (5-HI) levels in blood in hyperactive institutionalized mentally retarded patients before and after drug therapy revealed depression of 5-HI levels in 83% of hyperactive patients. In these patients with low serotonin levels, elevation of 5-HI levels in blood into the normal range by administration of a variety of psychoactive agents was associated with the disappearance of the hyperkinetic syndrome. Patients who remained hyperactive continued to have low 5-HI levels. Return of hyperactivity upon withdrawal of meidication in patients who were previously well controlled was associated with a fall in 5-HI levels. Adverse responses were seen in these patients when they were treated with medications usually tending to lower 5-HI levels in blood. Medications used in the treatment of hyperactivity may be classified as to whether they usually elevate, lower, or have no significant effect on 5-HI levels in blood.
对机构收容的多动型智力迟钝患者在药物治疗前后血液中5-羟吲哚（5-HI）水平的监测显示，83%的多动患者5-HI水平降低。在这些血清素水平较低的患者中，通过给予各种精神活性药物使血液中5-HI水平升高至正常范围与多动综合征的消失相关。仍多动的患者5-HI水平持续较低。先前病情得到良好控制的患者在停药后多动复发与5-HI水平下降相关。当用通常会降低血液中5-HI水平的药物治疗这些患者时，会出现不良反应。用于治疗多动的药物可根据其对血液中5-HI水平通常是升高、降低还是无显著影响进行分类。
