白细胞介素-6在小鼠急性和慢性贾第虫感染控制中的作用。
Role of interleukin-6 in the control of acute and chronic Giardia lamblia infections in mice.
作者信息
Zhou Ping, Li Erqiu, Zhu Nannan, Robertson Jason, Nash Theodore, Singer Steven M
机构信息
Department of Biology, Georgetown University, Washington, D.C. 20057, USA.
出版信息
Infect Immun. 2003 Mar;71(3):1566-8. doi: 10.1128/IAI.71.3.1566-1568.2003.
Abstract
In this study, we investigated the role of interleukin-6 (IL-6) in Giardia lamblia infections in mice. Elevated IL-6 expression was found in wild-type mice 15 days postinfection. Furthermore, IL-6-deficient mice controlled infections only slowly although normal immunoglobulin A production was observed. Thus, IL-6 is necessary for early control of acute G. lamblia infections.
摘要
在本研究中，我们调查了白细胞介素-6（IL-6）在小鼠贾第虫感染中的作用。在野生型小鼠感染后15天发现IL-6表达升高。此外，尽管观察到免疫球蛋白A产生正常，但IL-6缺陷小鼠对感染的控制较为缓慢。因此，IL-6是早期控制急性贾第虫感染所必需的。
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