PALM技术：兔角膜遮盖式光治疗性角膜切削术的组织学结果
The PALM Technique: histological findings of masked phototherapeutic keratectomy on rabbit corneas.
作者信息
Katsanevaki Vikentia J, Ginis Harilaos S, Naoumidi Irini I, Pallikaris Ioannis G
机构信息
University of Crete, Medical School, Vardinoyannion Eye Institute of Crete, Heraklion, Crete, Greece.
出版信息
BMC Ophthalmol. 2003 Feb 19;3:4. doi: 10.1186/1471-2415-3-4.
BACKGROUND
To compare the corneal healing response between conventional and phototherapeutic keratectomy through a masking agent, in rabbit corneas.
METHODS
24 adult rabbits underwent phototherapeutic keratectomy. Animals were divided in two groups: 12 received photoablation through a masking agent (PALM gel) and the remaining 12 received conventional phototherapeutic keratectomy of equal depth and served as control. Light and transmission electron microscopy was performed in specimens of both groups obtained: immediately after, four hours, one week, one, three and six months after treatment.
RESULTS
Reepitheliazation was complete within five days in all eyes. Light and transmission electron microscopy did not reveal any differences of the healing process in the experimental eyes compared to the controls.
CONCLUSION
Photoablation through the PALM technique did not result any evident alterations of the reepithelisation and stromal healing process.
背景
在兔角膜中，比较通过一种遮蔽剂进行的传统光治疗性角膜切削术与光治疗性角膜切削术之间的角膜愈合反应。
方法
24只成年兔接受了光治疗性角膜切削术。动物被分为两组：12只通过一种遮蔽剂（PALM凝胶）接受光消融，其余12只接受相同深度的传统光治疗性角膜切削术并作为对照。对两组获取的标本进行光镜和透射电镜检查：治疗后即刻、4小时、1周、1个月、3个月和6个月。
结果
所有眼睛在5天内上皮化完成。光镜和透射电镜检查显示，与对照组相比，实验眼的愈合过程没有任何差异。
结论
通过PALM技术进行的光消融没有导致上皮化和基质愈合过程出现任何明显改变。
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