婴儿期接种七价肺炎球菌结合疫苗后儿童的肺炎球菌鼻咽携带情况。
Pneumococcal nasopharyngeal carriage in children following heptavalent pneumococcal conjugate vaccination in infancy.
作者信息
Lakshman R, Murdoch C, Race G, Burkinshaw R, Shaw L, Finn A
机构信息
Sheffield Institute for Vaccine Studies, Sheffield Children's Hospital, Sheffield S10 2TH, UK.
出版信息
Arch Dis Child. 2003 Mar;88(3):211-4. doi: 10.1136/adc.88.3.211.
Abstract
AIMS
To ascertain whether the reduction in nasopharyngeal carriage of vaccine serotypes induced by pneumococcal conjugate vaccine (PnCV) administered to infants persists beyond the age of 2 years.
METHODS
Non-randomised, unblinded controlled study of 2-5 year old children who had received three doses of heptavalent PnCV (7VPnCV) in infancy and 23-valent pneumococcal polysaccharide vaccine at 13 months, and unimmunised controls. Nasopharyngeal swabs were taken in summer (150 vaccinated subjects, 126 controls) and winter (143 vaccinated subjects, 188 controls). The swabs were cultured and serotyped for Streptococcus pneumoniae.
RESULTS
Carriage rates (vaccinated subjects: 24.7% and 43.4%; controls: 27.0% and 41.0%, in summer and winter respectively) and carriage of vaccine serotypes (subjects: 10.0% and 30.0%; controls: 13.5% and 31.5%, in summer and winter respectively) were similar in the two groups.
CONCLUSIONS
Effects of vaccination in infancy on rates of nasal carriage of pneumococcus and serotype replacement in children living in a largely unvaccinated population are no longer evident by 2-5 years of age.
摘要
目的
确定婴儿接种肺炎球菌结合疫苗（PnCV）后，疫苗血清型鼻咽部携带率的降低在2岁以后是否持续存在。
方法
对在婴儿期接受三剂七价PnCV（7VPnCV）并在13个月时接种23价肺炎球菌多糖疫苗的2至5岁儿童以及未免疫的对照组进行非随机、非盲法对照研究。在夏季（150名接种疫苗的受试者，126名对照）和冬季（143名接种疫苗的受试者，188名对照）采集鼻咽拭子。对拭子进行培养并对肺炎链球菌进行血清分型。
结果
两组的携带率（接种疫苗的受试者：夏季为24.7%，冬季为43.4%；对照组：夏季为27.0%，冬季为41.0%）和疫苗血清型的携带率（受试者：夏季为10.0%，冬季为30.0%；对照组：夏季为13.5%，冬季为31.5%）相似。
结论
在2至5岁时，婴儿期接种疫苗对生活在大部分未接种疫苗人群中的儿童肺炎球菌鼻腔携带率和血清型替代率的影响不再明显。
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