Chen Adrienne, Boulton Ian C, Pongoski Jodi, Cochrane Alan, Gray-Owen Scott D
Department of Medical Genetics and Microbiology, University of Toronto, Ontario, Canada.
AIDS. 2003 Mar 7;17(4):625-8. doi: 10.1097/00002030-200303070-00019.
Gonorrhoea enhances the transmission of HIV through increased viral shedding and the increased probability of seroconversion among previously HIV-negative individuals. However, the mechanism(s) underlying these influences remain poorly understood. We demonstrated that exposure to Neisseria gonorrhoeae induces the nuclear factor kappa B-dependent transcription from the HIV-1 long terminal repeat in derivatives of the Jurkat CD4 T cell line. These data suggest that gonococcal infection directly impacts HIV-1 transmission through the localized stimulation of viral expression.
淋病通过增加病毒脱落以及先前HIV阴性个体血清转化概率的增加来增强HIV的传播。然而，这些影响背后的机制仍知之甚少。我们证明，在Jurkat CD4 T细胞系衍生物中，暴露于淋病奈瑟菌会诱导HIV-1长末端重复序列的核因子κB依赖性转录。这些数据表明，淋球菌感染通过局部刺激病毒表达直接影响HIV-1传播。
