Perkins R G, Kummerow F A
Biochim Biophys Acta. 1976 Mar 26;424(3):469-80. doi: 10.1016/0005-2760(76)90036-9.
More phosphatidylethanolamine and less phosphatidylinositol were present in the lipid of plasma membrane isolated from the liver of rats fed a diet containing the hepatocarcinogen, N-2-fluorenylacetamide than were present in the lipid of plasma membrane isolated from the liver of rats fed the basal diet. Phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin from the former membranes had relative amounts of 18 : 1 in their fatty acyl profiles that were 1.5--1.7 times the relative amount of 18 : 1 in the same phospholipid from the latter membranes. Furthermore, the former membranes contained 1.3 times more cholesterol and 1.35 times more sphingomyelin than the latter membrames.
与喂食基础日粮的大鼠肝脏分离的质膜脂质相比，喂食含肝癌致癌物N-2-芴基乙酰胺日粮的大鼠肝脏分离的质膜脂质中，磷脂酰乙醇胺含量更多，磷脂酰肌醇含量更少。前一种膜的磷脂酰胆碱、磷脂酰乙醇胺和鞘磷脂的脂肪酰谱中18:1的相对含量是后一种膜相同磷脂中18:1相对含量的1.5至1.7倍。此外，前一种膜的胆固醇含量比后一种膜多1.3倍，鞘磷脂含量比后一种膜多1.35倍。
