Plesiewicz E, Stepień E, Bolewska K, Wierzchowski K L
Biophys Chem. 1976 Mar;4(2):131-41. doi: 10.1016/0301-4622(76)85003-x.
Vapour pressure osmometric studies were performed on stacking self-association of 25 uracil derivatives variously C- and N-substituted with polar and alkyl groups in aqueous solution at various temperatures. The respective equilibrium association constants Kst were computed on the assumption of the isodesmic model of self-association (K2=K3=...=Kn=Kst). Enthalpies of association for most of the compounds studied were obtained from the temperature-dependence of Kst, according to the van 't Hoff equation. Analysis of the equilibrium and thermodynamic parameters in terms of the association mechanism demonstrated the involvement of classical hydrophobic interactiors in the stabilization of complexes of di-and higher alkylated uracils. Data for the derivatives substituted with polar groups proved consistent with the predominant involvement of dipole-induced dipole forces in the association.
在不同温度下，对25种在C和N位置被极性和烷基取代的尿嘧啶衍生物在水溶液中的堆积自缔合进行了蒸气压渗透测定研究。在自缔合等键模型（K2 = K3 =... = Kn = Kst）的假设下计算了各自的平衡缔合常数Kst。根据范特霍夫方程，从Kst的温度依赖性获得了大多数所研究化合物的缔合焓。根据缔合机制对平衡和热力学参数的分析表明，经典疏水相互作用参与了二烷基化和更高烷基化尿嘧啶配合物的稳定。极性基团取代衍生物的数据证明与缔合中偶极诱导偶极力的主要参与一致。
