脑脊液中的抗甲状腺抗体：它们在桥本脑病发病机制中的作用。
Antithyroid antibodies in the CSF: their role in the pathogenesis of Hashimoto's encephalopathy.
作者信息
Ferracci F, Moretto G, Candeago R M, Cimini N, Conte F, Gentile M, Papa N, Carnevale A
机构信息
Department of Neurology, Ospedale S. Martino, Belluno, Italy.
出版信息
Neurology. 2003 Feb 25;60(4):712-4. doi: 10.1212/01.wnl.0000048660.71390.c6.
Antithyroid antibodies and circulating immune complexes (CIC) were found in the CSF of six patients with Hashimoto's encephalopathy (HE) but not in the CSF of 21 controls. The synthesis of autoantibodies and CIC was intrathecal and their titers were independent of the patients' clinical status or therapy. Their presence in the CSF of patients with acute or subacute encephalopathy may be useful in diagnosing HE.
在6例桥本脑病（HE）患者的脑脊液中发现了抗甲状腺抗体和循环免疫复合物（CIC），而在21例对照者的脑脊液中未发现。自身抗体和CIC的合成是鞘内性的，其滴度与患者的临床状态或治疗无关。它们在急性或亚急性脑病患者脑脊液中的存在可能有助于诊断HE。
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