杏仁核内注射6-羟基多巴胺对大鼠回避反应的影响。
The effects of intra-amygdaloid injections of 6-hydroxy-dopamine on avoidance responding in rats.
作者信息
Ashford J, Jones B J
出版信息
Br J Pharmacol. 1976 Mar;56(3):255-61. doi: 10.1111/j.1476-5381.1976.tb07636.x.
Abstract
1 The effects of bilateral intra-amygdaloid injections of 6-hydroxydopamine (6-OHDA) on shuttle box avoidance acquisition, retention, and extinction, and passive avoidance acquisition were examined in rats. 2 Intra amygdaloid 6-OHDA injections produced catecholamine depletion in and around the amygdalae but failed to reduce striatal dopamine concentrations. 3 Conditioned avoidance acquisition was markedly inhibited in 6-OHDA-treated rats whereas retention and extinction were only slightly impaired. 4 Passive avoidance acquisition was slightly but significantly improved in rats with amygdaloid 6-OHDA lesions. 5 Treated rats showed no motor abnormalities, they were not hypoactive in a photocell activity cage and they performed as well as controls on a rotating rod. 6 It is suggested that the conditioned avoidance acquisition deficit in rats with amygdaloid 6-OHDA lesions may be related to an impairment of associative learning rather than to perceptual or motor disturbances.
摘要
- 研究了双侧杏仁核内注射6-羟基多巴胺（6-OHDA）对大鼠穿梭箱回避学习、记忆保持和消退以及被动回避学习的影响。2. 杏仁核内注射6-OHDA导致杏仁核及其周围的儿茶酚胺耗竭，但未能降低纹状体多巴胺浓度。3. 6-OHDA处理的大鼠的条件回避学习明显受到抑制，而记忆保持和消退仅略有受损。4. 杏仁核6-OHDA损伤的大鼠的被动回避学习略有但显著改善。5. 处理后的大鼠没有运动异常，它们在光电活动笼中没有活动减少，并且在旋转杆上的表现与对照组一样好。6. 有人认为，杏仁核6-OHDA损伤的大鼠的条件回避学习缺陷可能与联想学习受损有关，而不是与感知或运动障碍有关。
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