Lin Ho-Hsiung, Kao Jia-Horng, Chang Ting-Chen, Hsu Hong-Yuan, Chen Ding-Shinn
Department of Obstetrics and Gynecology, College of Medicine and the Hospital, National Taiwan University, Taipei, Taiwan.
J Med Virol. 2003 Apr;69(4):466-70. doi: 10.1002/jmv.10332.
To elucidate the impact of aging of hepatitis B carrier women on their viral replicative markers in a hepatitis B endemic area, all the parturients admitted to the Hospital were studied from 1985 to 2000. Serum hepatitis B surface (HBsAg) and hepatitis B e antigen (HBeAg) were tested by radioimmunoassay. Mann-Whitney U and Student's t-tests were used for statistical analysis. The results showed the yearly prevalence rate of HBsAg in pregnant women seemed stable with a mean of 12.0 +/- 1.1% during the period. The yearly positive rate of HBeAg among HBsAg-positive pregnant women varied between 30.4% and 42.6% from 1985 to 1992 and declined from 29.6% in 1993 to 18.1% in 2000. The mean ratio of HBeAg/HBsAg in carrier parturients was 24.7% [intraquantile range (IQR) 20.5-28.4] from 1993 to 2000, which was significantly lower than that of 32.4% (IQR 31.0-39.0) from 1985 to 1992 (P < 0.0001). The mean age of HBeAg-positive primiparas from 1993 to 2000 was 29.1 +/- 3.9 years and significantly higher than that of 28.0 +/- 3.7 years from 1985 to 1993 (P < 0.001), as well as in secundiparas 31.2 +/- 3.8 years vs. 30.1 +/- 3.4 years (P < 0.001) and in total parturients 30.3 +/- 4.2 years vs. 29.3 +/- 3.8 years (P < 0.001). Thus, no significant decrease of HBsAg carriage was observed in the past 16 years, whereas a decreased ratio of HBeAg/HBsAg was noted in carrier parturients in the past 8 years and the elderly HBeAg-positive parturients from 1993 to 2000 may be the cause.
为了阐明乙肝流行地区乙肝携带女性的年龄增长对其病毒复制标志物的影响，我们对1985年至2000年期间入住该医院的所有产妇进行了研究。采用放射免疫分析法检测血清乙肝表面抗原（HBsAg）和乙肝e抗原（HBeAg）。使用曼-惠特尼U检验和学生t检验进行统计分析。结果显示，在此期间孕妇中HBsAg的年患病率似乎稳定，平均为12.0±1.1%。1985年至1992年期间，HBsAg阳性孕妇中HBeAg的年阳性率在30.4%至42.6%之间变化，1993年从29.6%下降至2000年的18.1%。1993年至2000年期间，携带乙肝病毒产妇中HBeAg/HBsAg的平均比例为24.7%[四分位数间距（IQR）20.5 - 28.4]，显著低于1985年至1992年的32.4%（IQR 31.0 - 39.0）（P < 0.0001）。1993年至2000年期间，HBeAg阳性初产妇的平均年龄为29.1±3.9岁，显著高于1985年至1993年的28.0±3.7岁（P < 0.001），经产妇的平均年龄分别为31.2±3.8岁和30.1±3.4岁（P < 0.001），所有产妇的平均年龄分别为30.3±4.2岁和29.3±3.8岁（P < 0.001）。因此，在过去16年中未观察到HBsAg携带率显著下降，而在过去8年中携带乙肝病毒产妇的HBeAg/HBsAg比例下降，1993年至2000年期间年龄较大的HBeAg阳性产妇可能是原因所在。
