通过白细胞游走抑制测定对霍奇金脾脏组织的细胞免疫。

Cellular immunity to Hodgkin's splenic tissue measured by leucocyte migration inhibition.

作者信息

Hancock B W, Bruce L, Richmond J

出版信息

Br Med J. 1976 Mar 6;1(6009):556-7. doi: 10.1136/bmj.1.6009.556.

DOI:10.1136/bmj.1.6009.556

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1639378/

Abstract

Patients with lymphoreticular malignancy were shown by a leucocyte migration inhibition technique to have cellular immunity to Hodgkin's splenic tissue. Migration was significantly inhibited in 31 out of 55 patients with Hodgkin's lymphoma and 19 out of 39 patients with other types of lymphoma. Inhibition was also shown in only three out of 29 patients with other malignancy, one out of 23 normal volunteers, and one out of 25 patients with non-malignant disease. The splenic factor that inhibits leucocyte migration, which has yet to be isolated and identified, may be a helpful diagnostic tool in patients with suspected lymphoma.

摘要

采用白细胞游走抑制技术显示，淋巴网状恶性肿瘤患者对霍奇金脾组织具有细胞免疫。55例霍奇金淋巴瘤患者中有31例、39例其他类型淋巴瘤患者中有19例的游走受到显著抑制。29例其他恶性肿瘤患者中仅3例、23例正常志愿者中1例以及25例非恶性疾病患者中1例也显示出抑制作用。尚未分离和鉴定出的抑制白细胞游走的脾因子，可能对疑似淋巴瘤患者是一种有用的诊断工具。

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本文引用的文献

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Human lymphocyte migration as a parameter of hypersensitivity.人类淋巴细胞迁移作为超敏反应的一个参数。

Acta Med Scand. 1967 Feb;181(2):247-56. doi: 10.1111/j.0954-6820.1967.tb07255.x.

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An antigen in Hodgkin's disease tissue cultures: fluorescent antibody studies.霍奇金病组织培养中的一种抗原：荧光抗体研究。

Proc Natl Acad Sci U S A. 1974 Jun;71(6):2285-9. doi: 10.1073/pnas.71.6.2285.

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Ferritin synthesis in normal and leukaemic leukocytes.正常及白血病白细胞中的铁蛋白合成

Nature. 1974 Aug 16;250(467):584-6. doi: 10.1038/250584a0.

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A tumor antigen in tissue cultures derived from patients with Hodgkin's disease.一种源自霍奇金病患者的组织培养物中的肿瘤抗原。

Proc Natl Acad Sci U S A. 1973 May;70(5):1540-4. doi: 10.1073/pnas.70.5.1540.

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Ferritin, a Hodgkin's disease associated antigen.铁蛋白，一种与霍奇金病相关的抗原。

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An antigen in Hodgkin's disease tissue cultures: radioiodine-labeled antibody studies.霍奇金病组织培养中的一种抗原：放射性碘标记抗体研究。

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