de Sousa M, Smithyman A, Tan C
Am J Pathol. 1978 Feb;90(2):497-520.
In the present paper we apply the "ecotaxis hypothesis" to the analysis of lymphocyte distribution in Hodgkin's disease and other forms of lymphoid malignancy. The results lead us to consider the possiblity that metal-binding proteins, namely ferritin, transferrin and lactoferrin, play a role in lymphocyte ecotaxopahty. It is suggested that in Hodgkin's disease, a failure of lymph node and spleen monocytes to handle iron normally could explain most of the hematologic, immunologic, pathologic, and epidemiologic features of the disease.
在本论文中，我们将“趋生态假说”应用于对霍奇金病及其他形式淋巴恶性肿瘤中淋巴细胞分布的分析。结果使我们考虑金属结合蛋白，即铁蛋白、转铁蛋白和乳铁蛋白，在淋巴细胞趋生态异常中发挥作用的可能性。有人提出，在霍奇金病中，淋巴结和脾脏单核细胞正常处理铁的功能失败可以解释该疾病的大部分血液学、免疫学、病理学及流行病学特征。
