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Immunological effects of macrolides.
Curr Opin Infect Dis. 1998 Dec;11(6):681-8. doi: 10.1097/00001432-199812000-00006.
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Ciprofloxacin induces apoptosis and inhibits proliferation of human colorectal carcinoma cells.环丙沙星诱导人结肠癌细胞凋亡并抑制其增殖。
Br J Cancer. 2002 Feb 1;86(3):443-8. doi: 10.1038/sj.bjc.6600079.
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Mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced decrease in anti-CD3-activated CD4(+) T cells: the roles of apoptosis, Fas, and TNF.
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The effect of three broad-spectrum antimicrobials on mononuclear cell responses to encapsulated bacteria: evidence for down-regulation of cytokine mRNA transcription by trovafloxacin.三种广谱抗菌药物对单核细胞对包膜细菌反应的影响：曲伐沙星下调细胞因子mRNA转录的证据。
J Antimicrob Chemother. 2000 Dec;46(6):921-9. doi: 10.1093/jac/46.6.921.
5
Interference of antibacterial agents with phagocyte functions: immunomodulation or "immuno-fairy tales"?抗菌剂对吞噬细胞功能的干扰：免疫调节还是“免疫童话”？
Clin Microbiol Rev. 2000 Oct;13(4):615-50. doi: 10.1128/CMR.13.4.615.
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Effect of grepafloxacin on cytokine production in vitro.
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Apoptosis, oxidative metabolism and interleukin-8 production in human neutrophils exposed to azithromycin: effects of Streptococcus pneumoniae.阿奇霉素作用下人中性粒细胞的凋亡、氧化代谢及白细胞介素-8生成：肺炎链球菌的影响
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8
Effect of proinflammatory cytokines on the interplay between roxithromycin, HMR 3647, or HMR 3004 and human polymorphonuclear neutrophils.促炎细胞因子对罗红霉素、HMR 3647或HMR 3004与人类多形核中性粒细胞相互作用的影响。
Antimicrob Agents Chemother. 2000 Mar;44(3):511-21. doi: 10.1128/AAC.44.3.511-521.2000.
9
Differential modulatory effects of clarithromycin on the production of cytokines by a tumor.克拉霉素对肿瘤细胞因子产生的差异调节作用。
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10
Doxycycline induces Fas/Fas ligand-mediated apoptosis in Jurkat T lymphocytes.强力霉素诱导Jurkat T淋巴细胞中Fas/Fas配体介导的细胞凋亡。
Biochem Biophys Res Commun. 1999 Jul 5;260(2):562-7. doi: 10.1006/bbrc.1999.0929.

环丙沙星和罗红霉素对人 Jurkat T 淋巴细胞凋亡的体外作用。

In vitro effects of ciprofloxacin and roxithromycin on apoptosis of jurkat T lymphocytes.

作者信息

Jun Yong-Taek, Kim Hee-Jung, Song Min-Jin, Lim Ji-Hyang, Lee Dong-Gun, Han Kyung-Ja, Choi Su-Mi, Yoo Jin-Hong, Shin Wan-Shik, Choi Jung-Hyun

机构信息

Division of Infectious Diseases, Department of Internal Medicine, College of Medicine, Catholic University of Korea, Seoul, Korea.

出版信息

Antimicrob Agents Chemother. 2003 Mar;47(3):1161-4. doi: 10.1128/AAC.47.3.1161-1164.2003.

DOI:10.1128/AAC.47.3.1161-1164.2003
PMID:12604563
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC149341/
Abstract

Ciprofloxacin (CPFX) and roxithromycin (RXM) induced apoptosis of activated Jurkat T cells in vitro. CPFX showed concentration-dependent acceleration of apoptosis of activated Jurkat T cells by enhancing the expression of FasL and activities of caspase-3 and -8. RXM accelerated cell death, enhanced expression of FasL and caspase-3 but not caspase-8, and did not show the concentration dependency.

摘要

环丙沙星（CPFX）和罗红霉素（RXM）在体外可诱导活化的Jurkat T细胞凋亡。CPFX通过增强FasL的表达以及半胱天冬酶-3和-8的活性，呈浓度依赖性地加速活化的Jurkat T细胞凋亡。RXM加速细胞死亡，增强FasL和半胱天冬酶-3的表达，但不增强半胱天冬酶-8的表达，且不呈现浓度依赖性。