克拉霉素对肿瘤细胞因子产生的差异调节作用。
Differential modulatory effects of clarithromycin on the production of cytokines by a tumor.
作者信息
Sassa K, Mizushima Y, Kobayashi M
机构信息
First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama 930-0152, Japan.
出版信息
Antimicrob Agents Chemother. 1999 Nov;43(11):2787-9. doi: 10.1128/AAC.43.11.2787.
Abstract
In vitro treatment with clarithromycin inhibited the expression of the matrix metalloproteinase-9, transforming growth factor beta, and tumor necrosis factor alpha genes in 13762NF rat mammary adenocarcinoma cells. Transient enhancement, rather than inhibition, was observed for the interleukin-6 gene, and no significant change was observed for the tissue inhibitor of metalloproteinase-2 gene. Such an effect was not observed for cefotiam or gentamicin.
摘要
克拉霉素的体外处理抑制了13762NF大鼠乳腺腺癌细胞中基质金属蛋白酶-9、转化生长因子β和肿瘤坏死因子α基因的表达。白介素-6基因观察到短暂增强而非抑制，金属蛋白酶组织抑制剂-2基因未观察到显著变化。头孢替安或庆大霉素未观察到这种效果。
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