Shah Ami A, Casciola-Rosen Livia
Johns Hopkins University School of Medicine, Division of Rheumatology.
J Scleroderma Relat Disord. 2017 Sep-Dec;2(3):153-159. doi: 10.5301/jsrd.5000250. Epub 2017 Oct 5.
Emerging data suggest tantalizing links between cancer and systemic inflammatory rheumatic syndromes. In scleroderma, patients may have an increased risk of cancer secondary to chronic inflammation and damage from the disease, malignant transformation promoted by immunosuppressive therapies, a shared susceptibility to both cancer and autoimmunity, or a common inciting exposure. However, it is increasingly recognized that a subset of patients develop cancer around the time that scleroderma clinically manifests, raising the question of cancer-induced autoimmunity. In this review, we discuss data suggesting a mechanistic link between cancer and the development of scleroderma, and the clinical implications of these findings.
新出现的数据表明癌症与全身性炎性风湿综合征之间存在诱人的联系。在硬皮病中，患者患癌症的风险可能会增加，原因包括疾病导致的慢性炎症和损伤、免疫抑制疗法促进的恶性转化、对癌症和自身免疫的共同易感性或共同的诱发暴露。然而，越来越多的人认识到，一部分患者在硬皮病临床显现时患上癌症，这就引发了癌症诱发自身免疫的问题。在本综述中，我们讨论了表明癌症与硬皮病发展之间存在机制联系的数据，以及这些发现的临床意义。
