Menezes da Silva A
Clinica Uni;versitari;a de Cirugia III, Hospital de Pulido Valente, Alameda das Linhas de Torres 117 1750, Lisbon, Portugal.
Acta Trop. 2003 Feb;85(2):237-42. doi: 10.1016/s0001-706x(02)00271-1.
The appropriate treatment of hydatid cysts of the liver is determined by several factors, namely the patient, the cyst, the therapeutic resources and the physician. Characteristics of cysts, can be described by ultrasonography (US). Based on US images, we can classify hydatid cysts, according the evolutionary phase of the larval parasite and to choose the most appropriate therapeutic approach. US is also important to evaluate the efficacy of the treatment. Concerning the therapeutic methods, surgery had long been the only treatment available for the hydatid cyst of the liver. Beginning the 1970s benzimidazoles, Mebendazole and Albendazole, have been used for the treatment of the hydatid disease and in the early 1980s, with the development of diagnostic US, the deliberate puncture of abdominal cysts, particularly those in the liver, was evaluated this lead to puncture/aspiration, followed by injection of a scolicide which became a therapeutic method known as puncture, aspiration, injection and re-aspiration (PAIR). So, according to the cyst's characteristics based on US evaluation we can establish a therapeutic strategy: cysts type 1 and 3 may be treated by chemotherapy. Alternative treatment should be PAIR but only if the cysts cannot be treated with benzimidazoles. If there are contraindications for PAIR and chemotherapy the treatment should be surgical. Type 2 hydatid cysts can be treated by PAIR following initial treatment with benzimidazoles. If PAIR is not feasible or there is no evidence of degenerative changes after chemotherapy, surgery is indicated. Type 4 cysts are usually inactive and, in these cases, treatment is not indicated. If there is evidence that the cysts contents are still viable PAIR may be indicate. If PAIR is not possible, surgery is the method of choice. Cysts type 5 do not require treatment.
肝包虫囊肿的恰当治疗取决于多个因素,即患者、囊肿、治疗资源及医生。囊肿的特征可通过超声检查(US)来描述。基于超声图像,我们可根据幼虫寄生虫的演变阶段对肝包虫囊肿进行分类,并选择最合适的治疗方法。超声检查对于评估治疗效果也很重要。关于治疗方法,手术长期以来一直是肝包虫囊肿唯一可用的治疗方式。从20世纪70年代开始,苯并咪唑类药物,如甲苯达唑和阿苯达唑,已被用于治疗包虫病。在20世纪80年代初,随着诊断性超声的发展,人们对故意穿刺腹部囊肿,尤其是肝脏囊肿进行了评估,这导致了穿刺/抽吸,随后注入杀头节剂,这成为了一种被称为穿刺、抽吸、注射和再抽吸(PAIR)的治疗方法。所以,根据基于超声评估的囊肿特征,我们可以制定治疗策略:1型和3型囊肿可采用化疗治疗。替代治疗应为PAIR,但前提是囊肿不能用苯并咪唑类药物治疗。如果存在PAIR和化疗的禁忌证,则应进行手术治疗。2型肝包虫囊肿在先用苯并咪唑类药物进行初始治疗后可采用PAIR治疗。如果PAIR不可行或化疗后没有退行性改变的证据,则需进行手术治疗。4型囊肿通常无活性,在这些情况下,无需治疗。如果有证据表明囊肿内容物仍有活力,则可采用PAIR治疗。如果无法进行PAIR,则手术是首选方法。5型囊肿无需治疗。