Vujisić Sanja, Kupesić Sanja, Mihaljević Daria, Aksamija Alenka, Kurjak Asim
Department of Obstetrics and Gynecology, Medical School, University of Zagreb, Sveti Duh Hospital, Zagreb, Croatia.
Am J Reprod Immunol. 2002 Dec;48(6):355-60. doi: 10.1034/j.1600-0897.2002.01088.x.
To evaluate the role of CA 125 in prediction of in vitro fertilization and embryo transfer (IVF/ET) outcome.
Serum CA 125 concentrations were evaluated in the spontaneous and stimulated cycles of 33 patients. CA 125 was measured using a microparticle enzyme immunoassay (MEIA) (Abbott, Diagnostics, USA). Follicular growth, endometrial thickness and subendometrial blood flow were evaluated by transvaginal color Doppler ultrasound. Statistical analysis was performed by Wilcoxon rank-sum test and Friedman test.
There was no statistically significant difference (P > 0.05) of CA 125 values between spontaneous and stimulated cycles, and between pregnant and non-pregnant patients. A CA 125 rise from the late proliferative to the early secretory phase (P < 0.05) was obtained only in the stimulated cycles. There was no relationship between CA 125, follicle number, endometrial thickness and resistance index of the subendometrial vessels.
CA 125 levels are not predictive of ovarian and endometrial response. Hormonal stimulation does not effect serum CA 125 concentration. There was no influence of CA 125 levels on IVF/ET outcome in stimulated cycles.
评估CA 125在预测体外受精与胚胎移植（IVF/ET）结局中的作用。
对33例患者的自然周期和促排卵周期的血清CA 125浓度进行评估。采用微粒酶免疫分析（MEIA）（美国雅培诊断公司）检测CA 125。经阴道彩色多普勒超声评估卵泡生长、子宫内膜厚度和子宫内膜下血流。采用Wilcoxon秩和检验和Friedman检验进行统计分析。
自然周期与促排卵周期之间、妊娠患者与未妊娠患者之间的CA 125值无统计学显著差异（P>0.05）。仅在促排卵周期中，CA 125从增殖晚期到分泌早期有所升高（P<0.05）。CA 125与卵泡数量、子宫内膜厚度及子宫内膜下血管阻力指数之间无相关性。
CA 125水平不能预测卵巢和子宫内膜反应。激素刺激不影响血清CA 125浓度。在促排卵周期中，CA 125水平对IVF/ET结局无影响。
