McGlumphy Edwin A, Peterson Larry J, Larsen Peter E, Jeffcoat Marjorie K
College of Dentistry, The Ohio State University, Columbus, Ohio 43218-2357, USA.
Int J Oral Maxillofac Implants. 2003 Jan-Feb;18(1):82-92.
Controversy over the long-term clinical effectiveness of hydroxyapatite (HA)-coated dental implants still persists, despite numerous clinical studies documenting high survival rates. The Ohio State University College of Dentistry undertook a 5-year prospective study of 429 HA-coated cylindric implants placed into 121 patients to determine the long-term clinical performance of the implants.
All study subjects were patients screened and evaluated in the university's dental clinic by one of the principal investigators and one member of the surgical team. A total of 429 HA-coated implants were placed in 121 patients. The Ohio State University Human Subjects Committee approved and reviewed this study.
At the time of this report, 375 implants had completed 5 years of clinical follow-up. Beyond the 5-year limit of the study, 282 implants had completed 6 years and 114 implants had completed 7 years of clinical monitoring. The cumulative survival rate was 96% at 5 years and 95% at 7 years of follow-up. Mean combined mesial/distal bone loss was 1.2 mm in the mandible and 1.4 mm in the maxilla after 5 years of functional loading. Implant failures were most commonly associated with short implants or angled abutments.
Prospective clinical data are extremely valuable for clinicians evaluating the reliability of dental implant systems. In the present study, the implants achieved 100% osseointegration with minimal marginal bone loss, and 96% of the implants remained in function at 5 years.
The HA-coated cylindric implants in this study provided a predictable means of oral rehabilitation.
尽管众多临床研究证明羟基磷灰石（HA）涂层牙种植体具有很高的生存率，但关于其长期临床有效性的争议仍然存在。俄亥俄州立大学牙科学院对121名患者植入的429枚HA涂层圆柱形种植体进行了为期5年的前瞻性研究，以确定这些种植体的长期临床性能。
所有研究对象均为在大学牙科诊所由一名主要研究者和一名手术团队成员进行筛查和评估的患者。共对121名患者植入了429枚HA涂层种植体。该研究经俄亥俄州立大学人类受试者委员会批准和审查。
在本报告发布时，375枚种植体已完成5年的临床随访。超出研究的5年期限后，282枚种植体完成了6年的临床监测，114枚种植体完成了7年的临床监测。随访5年时的累积生存率为96%，7年时为95%。功能负载5年后，下颌骨平均近中/远中骨吸收为1.2mm，上颌骨为1.4mm。种植体失败最常见于种植体较短或基台有角度的情况。
前瞻性临床数据对于临床医生评估牙种植系统的可靠性极其有价值。在本研究中，种植体实现了100%的骨结合，边缘骨吸收极少，96%的种植体在5年后仍在发挥功能。
本研究中的HA涂层圆柱形种植体为口腔修复提供了一种可预测的方法。
