来自台湾柳珊瑚琼氏拟柳珊瑚的新苔藓虫素。

New briaranes from the Taiwanese gorgonian Junceella juncea.

作者信息

Shen Ya-Ching, Lin Yu-Chi, Ko Chin-Lien, Wang Li-Tang

机构信息

Institute of Marine Resources, National Sun Yat-sen University, 70 Lien-Hai Road, Kaohsiung, Taiwan, Republic of China.

出版信息

J Nat Prod. 2003 Feb;66(2):302-5. doi: 10.1021/np0203584.

DOI:10.1021/np0203584

PMID:12608873

Abstract

In addition to the known junceelolide C (4), three new briaranes, juncenolides B (1), C (2), and D (3), have been isolated from the acetone extract of a red Gorgonian Junceella juncea collected in Taiwan. The structures of 1-3 were elucidated on the basis of FABMS and 2D NMR techniques including COSY, HMQC, HMBC, and NOESY experiments. Among them, compound 2 exhibited mild cytotoxicity against human liver carcinoma (HEPA 59T/VGH) and oral epidermoid (KB) carcinoma cells.

摘要

除了已知的柔枝柳珊瑚内酯C（4）外，还从采集于台湾的红色柳珊瑚柔枝柳珊瑚的丙酮提取物中分离出三种新的 briaranes，即柔枝柳珊瑚内酯B（1）、C（2）和D（3）。通过FABMS以及包括COSY、HMQC、HMBC和NOESY实验在内的二维核磁共振技术确定了1 - 3的结构。其中，化合物2对人肝癌（HEPA 59T/VGH）和口腔表皮样（KB）癌细胞表现出轻微的细胞毒性。