脆小扇海绵素E - K，源自脆小扇海绵的蔷薇烷二萜类化合物。

Frajunolides E-K, briarane diterpenes from Junceella fragilis.

作者信息

Liaw Chia-Ching, Shen Ya-Ching, Lin Yun-Sheng, Hwang Tsong-Long, Kuo Yao-Haur, Khalil Ashraf Taha

机构信息

Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, Republic of China.

出版信息

J Nat Prod. 2008 Sep;71(9):1551-6. doi: 10.1021/np800126f. Epub 2008 Sep 6.

DOI:10.1021/np800126f

PMID:18774864

Abstract

Chemical investigation of the gorgonian octocoral Junceella fragilis, collected in Taiwan, resulted in the isolation of seven new briarane-type diterpenes, frajunolides E-K (1-7), in addition to 14 known briaranes, praelolide, junceellin, junceellolides A-E, and K, 11a,20a-epoxy-4-deacetoxyjunceelolide D, umbraculolide A, junceellonoid A, and juncins Y, Z, and ZI, as well as ergosterol peroxide. The structures of 1-7 were determined by analysis of HRESIMS and 2D NMR spectroscopic data. Cytotoxicity and in vitro anti-inflammatory activities of compounds 1-7 were also evaluated.

摘要

对采集于台湾的柳珊瑚八放珊瑚脆弱柔枝柳珊瑚进行化学研究，除了得到14种已知的 briaranes、前洛利德、柔枝柳珊瑚素、柔枝柳珊瑚内酯A - E和K、11a,20a - 环氧 - 4 - 脱乙酰氧基柔枝柳珊瑚内酯D、伞花内酯A、柔枝柳珊瑚类化合物A以及柔枝柳珊瑚素Y、Z和ZI，还有过氧化麦角甾醇外，还分离出7种新的 briarane 型二萜类化合物，即脆枝柔枝柳珊瑚醇E - K（1 - 7）。通过高分辨电喷雾电离质谱（HRESIMS）和二维核磁共振光谱数据的分析确定了1 - 7的结构。还评估了化合物1 - 7的细胞毒性和体外抗炎活性。