丛柳珊瑚素A和B，来自软珊瑚带纹丛柳珊瑚的一种新结构类型的细胞毒性二萜类化合物。

Cespitulones A and B, cytotoxic diterpenoids of a new structure class from the soft coral Cespitularia taeniata.

作者信息

Lin Yu-Chi, Wang Shih-Sheng, Chen Chung-Hsiung, Kuo Yao-Haur, Shen Ya-Ching

机构信息

School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan.

Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.

出版信息

Mar Drugs. 2014 Jun 5;12(6):3477-86. doi: 10.3390/md12063477.

DOI:10.3390/md12063477

PMID:24905485

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4071587/

Abstract

Two novel diterpenoids, cespitulones A (1) and B (2), were isolated from extracts of the soft coral Cespitularia taeniata. Both compounds possess an unprecedented bicyclo [10.3.1] ring system with C-C bond connections between C-10 and C-20, and between C-20 and C-11. Their structures were elucidated on the basis of extensive spectroscopic analyses. Compound 1 exhibited significant cytotoxicity against human medulloblastoma and colon adenocarcinoma cancer cells.

摘要

从软珊瑚带纹团块珊瑚（Cespitularia taeniata）的提取物中分离出两种新型二萜类化合物，团块二萜A（1）和B（2）。这两种化合物都具有前所未有的双环[10.3.1]环系统，在C-10与C-20之间以及C-20与C-11之间存在碳-碳键连接。它们的结构通过广泛的光谱分析得以阐明。化合物1对人髓母细胞瘤和结肠腺癌癌细胞表现出显著的细胞毒性。