May Theodor W., Pfäfflin Margarete, Cramer Joyce A.
Gesellschaft für Epilepsieforschung, Bielefeld, Germany
Epilepsy Behav. 2001 Apr;2(2):106-114. doi: 10.1006/ebeh.2001.0170.
The purpose of this work was to assess the psychometric properties of the German Translation of the Quality of Life in Epilepsy Inventory, QOLIE-31. Internal consistency, construct and criterion validity, and responsiveness were tested in 509 patients with epilepsy who were administered the questionnaires at application or at admittance to the epilepsy center Bethel. Construct validity was tested in patients with different seizure frequencies and different degrees of tolerability of antiepileptic drug (AED) therapy (adverse effects). The scales Epilepsy-Related Fears und Restrictions in Daily Life due to Epilepsy were used as criterion measures. Test-retest reliability (long-term stability) and responsiveness of the questionnaire were analyzed in subgroups of patients who responded to the questionnaires a second time (n = 256). Cronbach's alpha of the QOLIE-31 was 0.94 and varied between 0.76 and 0.90 for the seven subscales. The correlations of the QOLIE with Epilepsy-Related Fears and Restrictions in Daily Life revealed high correlations between Epilepsy-Related Fears and the QOLIE subscale Seizure Worry (r = 0.81, P < 0.01) and the total score (r = 0.62, P < 0.01) and between Restrictions in Daily Life and the QOLIE subscale Social Functioning (r = 0.71) and the total score (r = 0.70, P < 0.01). Seizure frequency had a significant effect especially on the QOLIE subscales Social Functioning, Seizure Worry, and Overall QOL, whereas tolerability of AED therapy affected especially the subscales Medication Effects, Overall QOL, and Energy-Fatigue. The test-retest reliability (intraclass correlation coefficient) was 0.79 for the overall score and varied between 0.59 and 0.78 for the seven subscales. The German Translation of QOLIE-31 is a reliable and valid questionnaire with which to assess QOL in patients with epilepsy and is conceptually similar to the English version. It is a sensitive questionnaire with respect to seizure frequency and tolerability of antiepileptic drug treatment.
这项研究的目的是评估癫痫患者生活质量量表（QOLIE - 31）德文版的心理测量特性。对509例癫痫患者进行了内部一致性、结构效度、效标效度和反应度测试，这些患者在癫痫中心贝特尔就诊时或入院时接受了问卷调查。在不同癫痫发作频率和不同抗癫痫药物（AED）治疗耐受性（不良反应）的患者中测试了结构效度。将癫痫相关恐惧量表和癫痫导致的日常生活限制量表用作效标测量。对第二次回复问卷的患者亚组（n = 256）分析了问卷的重测信度（长期稳定性）和反应度。QOLIE - 31的Cronbach's α系数为0.94，七个子量表的α系数在0.76至0.90之间。QOLIE与癫痫相关恐惧和日常生活限制之间的相关性显示，癫痫相关恐惧与QOLIE子量表癫痫担忧（r = 0.81，P < 0.01）和总分（r = 0.62，P < 0.01）之间以及日常生活限制与QOLIE子量表社会功能（r = 0.71）和总分（r = 0.70，P < 0.01）之间存在高度相关性。癫痫发作频率尤其对QOLIE子量表社会功能、癫痫担忧和总体生活质量有显著影响，而AED治疗的耐受性尤其影响子量表药物副作用、总体生活质量和精力 - 疲劳。总分的重测信度（组内相关系数）为0.79，七个子量表的重测信度在0.59至0.78之间。QOLIE - 31德文版是一种可靠且有效的问卷，可用于评估癫痫患者的生活质量，在概念上与英文版相似。它是一种对癫痫发作频率和抗癫痫药物治疗耐受性敏感的问卷。
