Departamento de Epilepsia, Instituto Nacional de Ciencias Neurológicas, Lima, Peru.
School of Medicine, Trinity College Dublin, Dublin, Ireland; Cysticercosis Unit, Instituto Nacional de Ciencias Neurológicas, Lima, Peru; Center for Global Health, Universidad Peruana Cayetano Heredia, Lima, Peru.
Epilepsy Behav. 2022 Jun;131(Pt A):108668. doi: 10.1016/j.yebeh.2022.108668. Epub 2022 Apr 25.
Neurocysticercosis (NCC) is a common cause of late-onset epilepsy worldwide, but there is still minimal information regarding its impact on a patient's quality of life. This study evaluated quality of life in a series of patients with epilepsy secondary to NCC using the QOLIE (Quality of Life in Epilepsy)-31 questionnaire.
This cross-sectional study included 155 Peruvian patients between 16 and 70 years of age with epilepsy due to viable intraparenchymal NCC, who enrolled in two trials of anti-parasitic treatment during the period 2006-2011. The QOLIE-31 questionnaire was applied before the onset of anti-parasitic treatment. The associations between QOLIE-31 scores, sociodemographic characteristics, clinical, and neuroimaging data were analyzed with Kruskal-Wallis test and generalized linear models (GLM).
The average QOLIE-31 score was 55.8 (SD ± 7.6), with 119 individuals (76.8%) scoring in the poor quality-of-life category. Generalized tonic-clonic seizures and secondarily generalized epileptic seizures were associated with a lower QOLIE-31, as well as a low level of education with a value of p = 0.05. There were no associations between QOLIE-31 scores and other variables such as sex, age, antiepileptic medication, number of parasitic cysts, and number of compromised brain regions. On multivariate analysis, a greater number of generalized epileptic seizures maintained a statistically significant association with detrimental QOLIE-31 scores.
Quality of life is affected in NCC, mainly in relation to the number of prior generalized epileptic seizures.
神经囊虫病（NCC）是全球引起迟发性癫痫的常见原因，但关于其对患者生活质量的影响的信息仍然很少。本研究使用 QOLIE（癫痫生活质量）-31 问卷评估了一系列由 NCC 引起的癫痫患者的生活质量。
这项横断面研究纳入了 2006 年至 2011 年期间参与两项抗寄生虫治疗试验的 155 名秘鲁患者，这些患者年龄在 16 至 70 岁之间，患有因活的脑实质内 NCC 引起的癫痫。在开始抗寄生虫治疗之前，应用 QOLIE-31 问卷进行评估。采用 Kruskal-Wallis 检验和广义线性模型（GLM）分析 QOLIE-31 评分与社会人口统计学特征、临床和神经影像学数据之间的关系。
平均 QOLIE-31 评分为 55.8（SD ± 7.6），有 119 名患者（76.8%）评分处于生活质量差的类别。全面强直阵挛性发作和继发性全面性癫痫发作与 QOLIE-31 评分较低相关，文化程度较低与 p 值=0.05 相关。QOLIE-31 评分与其他变量如性别、年龄、抗癫痫药物、寄生虫囊肿数量和受影响的脑区数量之间无相关性。在多变量分析中，更多的全面性癫痫发作与 QOLIE-31 评分下降有统计学显著相关性。
NCC 会影响生活质量，主要与先前全面性癫痫发作的次数有关。
